TMED4

Entrez Summary: N/A
UniProt Summary: Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

COPII-coated ER to Golgi transport vesicle
endoplasmic reticulum-Golgi intermediate compartment
Golgi organization
positive regulation of I-kappaB kinase/NF-kappaB signaling
endoplasmic reticulum to Golgi vesicle-mediated transport
regulation of I-kappaB kinase/NF-kappaB signaling
Golgi vesicle transport
endomembrane system organization
endoplasmic reticulum membrane
Golgi apparatus
intracellular protein transport
endoplasmic reticulum
positive regulation of intracellular signal transduction
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport