TMEM109

Entrez Summary: N/A
UniProt Summary: May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:23542032). Can form voltage-gated calcium and potassium channels in vitro (By similarity). {ECO:0000250|UniProtKB:O77751, ECO:0000269|PubMed:23542032}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Thapsigargin 0.005μM R07 exp407	-1.72
GSK2606414 1μM R05 exp236	1.92

nuclear outer membrane
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
cellular response to gamma radiation
sarcoplasmic reticulum membrane
voltage-gated ion channel activity
intrinsic apoptotic signaling pathway by p53 class mediator
response to gamma radiation
cellular response to ionizing radiation
intrinsic apoptotic signaling pathway in response to DNA damage
signal transduction by p53 class mediator
response to ionizing radiation
intrinsic apoptotic signaling pathway
cellular response to radiation
apoptotic signaling pathway
cellular response to environmental stimulus
cellular response to abiotic stimulus
response to radiation
regulation of ion transmembrane transport
regulation of transmembrane transport
regulation of ion transport
molecular function
cellular response to DNA damage stimulus
apoptotic process
ion transmembrane transport
negative regulation of cell death
programmed cell death
cell death
response to abiotic stimulus
transmembrane transport
ion transport
regulation of cell death
intracellular signal transduction
cellular response to stress
regulation of transport