TMEM14B

Entrez Summary: N/A
UniProt Summary: Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions. {ECO:0000269|PubMed:29033352}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DUF2416
Tmemb 14

neural precursor cell proliferation
cerebral cortex development
regulation of G1/S transition of mitotic cell cycle
regulation of cell cycle G1/S phase transition
pallium development
telencephalon development
forebrain development
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
cell population proliferation
regulation of mitotic cell cycle
brain development
regulation of cell cycle process
head development
central nervous system development
regulation of cell cycle