TMEM88

Entrez Summary: N/A
UniProt Summary: Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development. {ECO:0000269|PubMed:23924634}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PDZ domain binding
negative regulation of canonical Wnt signaling pathway
protein stabilization
protein localization to plasma membrane
negative regulation of Wnt signaling pathway
protein localization to cell periphery
regulation of canonical Wnt signaling pathway
regulation of protein stability
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
protein localization to membrane
cell-cell signaling
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
cellular protein localization
cellular macromolecule localization
negative regulation of response to stimulus