TMPRSS6

Entrez Summary: The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CI-1040 9.5μM R08 exp472	-1.72
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.7

self proteolysis
fibrinolysis
membrane protein proteolysis
collagen catabolic process
negative regulation of BMP signaling pathway
negative regulation of blood coagulation
negative regulation of hemostasis
negative regulation of coagulation
cellular iron ion homeostasis
collagen metabolic process
extracellular matrix disassembly
negative regulation of wound healing
regulation of blood coagulation
iron ion homeostasis
regulation of hemostasis
regulation of coagulation
negative regulation of response to wounding
regulation of BMP signaling pathway
cellular transition metal ion homeostasis
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
transition metal ion homeostasis
regulation of wound healing
negative regulation of cellular response to growth factor stimulus
serine-type endopeptidase activity
regulation of response to wounding
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to growth factor stimulus
extracellular matrix organization
negative regulation of response to external stimulus
extracellular structure organization
cellular component disassembly
regulation of body fluid levels
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis