TMTC3

Entrez Summary: This gene encodes a protein that belongs to the transmembrane and tetratricopeptide repeat-containing protein family. [provided by RefSeq, May 2010].
UniProt Summary: Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response. {ECO:0000269|PubMed:21603654}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Aphidicolin 0.04μM R06 exp263	1.73
MLN-4924 0.2μM R00 exp21	1.83

dolichyl-phosphate-mannose-protein mannosyltransferase activity
protein O-linked mannosylation
mannosyltransferase activity
protein mannosylation
mannosylation
positive regulation of proteasomal protein catabolic process
protein O-linked glycosylation
positive regulation of proteolysis involved in cellular protein catabolic process
positive regulation of cellular protein catabolic process
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process
regulation of cellular protein catabolic process
protein glycosylation
macromolecule glycosylation
response to endoplasmic reticulum stress
glycosylation
glycoprotein biosynthetic process
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
glycoprotein metabolic process
positive regulation of catabolic process
carbohydrate derivative biosynthetic process
regulation of proteolysis
regulation of cellular catabolic process
regulation of catabolic process
endoplasmic reticulum
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
positive regulation of cellular protein metabolic process
cellular response to stress
positive regulation of protein metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process