TNFSF8

Entrez Summary: N/A
UniProt Summary: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Disulfiram 4.3μM R06 exp281	1.74
FK-506 30μM R07 exp359	1.81

CD8-positive, alpha-beta T cell differentiation
CD8-positive, alpha-beta T cell activation
tumor necrosis factor receptor binding
alpha-beta T cell differentiation
alpha-beta T cell activation
defense response to Gram-positive bacterium
tumor necrosis factor-mediated signaling pathway
T cell differentiation
regulation of T cell proliferation
cytokine activity
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
regulation of leukocyte proliferation
T cell activation
lymphocyte differentiation
cellular response to tumor necrosis factor
response to tumor necrosis factor
regulation of T cell activation
defense response to bacterium
leukocyte differentiation
signaling receptor binding
lymphocyte activation
regulation of lymphocyte activation
hemopoiesis
regulation of leukocyte activation
hematopoietic or lymphoid organ development
regulation of cell activation
immune system development
cytokine-mediated signaling pathway
response to bacterium
leukocyte activation
defense response to other organism
cellular response to cytokine stimulus
cell activation
response to cytokine
cell-cell signaling
positive regulation of transcription by RNA polymerase II
response to other organism
response to external biotic stimulus
response to biotic stimulus