TNKS2

Gene Information

Official Symbol: TNKS2
Official Name: tankyrase 2
Aliases and Previous Symbols: N/A
Entrez ID: 80351
UniProt: Q9H2K2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity. {ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:11802774, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:23622245}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Methotrexate 0.01μM R08 exp501	1.82
Temozolomide 200μM R04 exp189	1.87
2-Deoxy-D-glucose 800μM R05 exp214	1.89
VER-155008 3.9μM R06 exp301	1.96
LY2090314 0.003μM R08 exp500 no dilution day6	4.14
LY2090314 0.003μM R08 exp499	4.45

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12902
Expression level (log2 read counts): 7.21

Expression Distribution

Ank
Ank 2
SAM 2
PARP
SAM 1

protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
protein localization to chromosome, telomeric region
protein ADP-ribosylase activity
positive regulation of telomere capping
pericentriolar material
regulation of telomere capping
negative regulation of telomere maintenance via telomere lengthening
NAD+ ADP-ribosyltransferase activity
protein ADP-ribosylation
positive regulation of telomere maintenance via telomerase
positive regulation of telomere maintenance via telomere lengthening
negative regulation of telomere maintenance
positive regulation of telomere maintenance
regulation of telomere maintenance via telomerase
regulation of telomere maintenance via telomere lengthening
protein localization to chromosome
regulation of multicellular organism growth
positive regulation of DNA biosynthetic process
regulation of telomere maintenance
multicellular organism growth
nuclear chromosome, telomeric region
regulation of DNA biosynthetic process
negative regulation of DNA metabolic process
negative regulation of chromosome organization
positive regulation of canonical Wnt signaling pathway
positive regulation of chromosome organization
positive regulation of Wnt signaling pathway
nuclear envelope
positive regulation of DNA metabolic process
regulation of canonical Wnt signaling pathway
protein polyubiquitination
regulation of developmental growth
enzyme binding
regulation of chromosome organization
regulation of DNA metabolic process
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
negative regulation of organelle organization