TPD52L1

Gene Information

Official Symbol: TPD52L1
Official Name: TPD52 like 1
Aliases and Previous Symbols: N/A
Entrez ID: 7164
UniProt: Q16890
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 2μM R07 exp306	-1.76
Tubastatin-A 2.5μM R07 exp417	-1.75
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.72
FBS-Wisent 0.1 R07 exp426	1.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8868
Expression level (log2 read counts): 2.64

Expression Distribution

G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
positive regulation of JNK cascade
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
positive regulation of apoptotic signaling pathway
regulation of JNK cascade
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
positive regulation of MAP kinase activity
mitotic cell cycle phase transition
cell cycle phase transition
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
regulation of apoptotic signaling pathway
protein heterodimerization activity
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
positive regulation of kinase activity
mitotic cell cycle process
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of transferase activity
mitotic cell cycle
positive regulation of cell death
perinuclear region of cytoplasm
regulation of cellular response to stress
regulation of MAPK cascade
regulation of protein kinase activity
regulation of kinase activity
protein homodimerization activity
regulation of transferase activity
cell cycle process
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
identical protein binding
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process