TPGS1

Entrez Summary: N/A
UniProt Summary: May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

tubulin-glutamic acid ligase activity
protein polyglutamylation
sperm axoneme assembly
peptidyl-glutamic acid modification
axoneme assembly
sperm motility
flagellated sperm motility
microtubule bundle formation
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
motile cilium
adult behavior
spermatid development
spermatid differentiation
vesicle localization
microtubule binding
germ cell development
axon
microtubule
cilium assembly
cellular process involved in reproduction in multicellular organism
cilium organization
dendrite
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
plasma membrane bounded cell projection assembly
cell projection assembly
synaptic signaling
microtubule cytoskeleton organization
centrosome
spermatogenesis
male gamete generation
behavior
organelle localization
developmental process involved in reproduction
microtubule-based process
gamete generation
organelle assembly
multicellular organismal reproductive process