TPPP3

Entrez Summary: N/A
UniProt Summary: Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis. {ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:19633818}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mdivi-1 15μM R05 exp217	-2.07
Mubritinib 0.2μM R01 exp48	-1.89
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.87
Atovaquone 15μM R08 exp451	-1.82
PFI-2 4μM R05 exp239	-1.74
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	1.71
HMS-I1 1μM R01 exp46	1.78
MK2206 4μM R08 exp504	1.89

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

microtubule bundle
microtubule polymerization
microtubule polymerization or depolymerization
tubulin binding
protein polymerization
microtubule bundle formation
positive regulation of protein polymerization
regulation of protein polymerization
positive regulation of protein complex assembly
microtubule
regulation of protein complex assembly
supramolecular fiber organization
microtubule cytoskeleton organization
positive regulation of cellular component biogenesis
microtubule-based process
perinuclear region of cytoplasm
cellular protein-containing complex assembly
regulation of cellular component biogenesis
cytoskeleton organization
positive regulation of cellular component organization
protein-containing complex assembly
protein-containing complex subunit organization