TRAF3

Gene Information

Official Symbol: TRAF3
Official Name: TNF receptor associated factor 3
Aliases and Previous Symbols: N/A
Entrez ID: 7187
UniProt: Q13114
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010].
UniProt Summary: Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docetaxel 0.002μM R01 exp45	-2.33
Arsenate 40μM R06 exp264	-1.84
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.8
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.74
Etoposide 0.3μM R05 exp199	1.87

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14846
Expression level (log2 read counts): 5.48

Expression Distribution

MATH
zf-TRAF

Toll signaling pathway
CD40 receptor complex
thioesterase binding
TRIF-dependent toll-like receptor signaling pathway
tumor necrosis factor receptor binding
MyD88-independent toll-like receptor signaling pathway
regulation of interferon-beta production
cytoplasmic side of plasma membrane
regulation of defense response to virus
negative regulation of NF-kappaB transcription factor activity
protein phosphatase binding
toll-like receptor signaling pathway
tumor necrosis factor-mediated signaling pathway
regulation of type I interferon production
pattern recognition receptor signaling pathway
negative regulation of DNA-binding transcription factor activity
innate immune response-activating signal transduction
cellular response to tumor necrosis factor
ubiquitin-protein transferase activity
activation of innate immune response
response to tumor necrosis factor
endosome
protein deubiquitination
ubiquitin protein ligase binding
protein modification by small protein removal
positive regulation of innate immune response
positive regulation of response to biotic stimulus
regulation of DNA-binding transcription factor activity
regulation of innate immune response
protein kinase binding
regulation of immune effector process
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
immune response-activating signal transduction
protein-containing complex
immune response-regulating signaling pathway
positive regulation of response to external stimulus
activation of immune response
cytokine-mediated signaling pathway