TRAF6
Gene Information
- Official Symbol: TRAF6
- Official Name: TNF receptor associated factor 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 7189
- UniProt: Q9Y4K3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c- Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. {ECO:0000269|PubMed:11057907, ECO:0000269|PubMed:12140561, ECO:0000269|PubMed:16378096, ECO:0000269|PubMed:17135271, ECO:0000269|PubMed:18093978, ECO:0000269|PubMed:18347055, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:19465916, ECO:0000269|PubMed:19675569, ECO:0000269|PubMed:19713527, ECO:0000269|PubMed:8837778}.
Pfam Domains GO Terms
Pfam Domains
| zf-C3HC4 |
| MATH |
| zf-TRAF |
GO Terms
| positive regulation of interleukin-12 biosynthetic process |
| positive regulation of lipopolysaccharide-mediated signaling pathway |
| regulation of interleukin-12 biosynthetic process |
| protein kinase B binding |
| CD40 receptor complex |
| thioesterase binding |
| positive regulation of leukocyte adhesion to vascular endothelial cell |
| positive regulation of interleukin-6 biosynthetic process |
| toll-like receptor 9 signaling pathway |
| activation of NF-kappaB-inducing kinase activity |
| mitogen-activated protein kinase kinase kinase binding |
| myeloid dendritic cell differentiation |
| positive regulation of T cell cytokine production |
| regulation of immunoglobulin secretion |
| regulation of leukocyte adhesion to vascular endothelial cell |
| T-helper 1 type immune response |
| membrane protein intracellular domain proteolysis |
| myeloid dendritic cell activation |
| regulation of interleukin-6 biosynthetic process |
| bone resorption |
| regulation of lipopolysaccharide-mediated signaling pathway |
| positive regulation of transcription regulatory region DNA binding |
| positive regulation of osteoclast differentiation |
| nucleotide-binding oligomerization domain containing signaling pathway |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
| positive regulation of interleukin-2 production |
| tumor necrosis factor receptor binding |
| regulation of T cell cytokine production |
| dendritic cell differentiation |
| MyD88-dependent toll-like receptor signaling pathway |
| ubiquitin conjugating enzyme binding |
| cytoplasmic pattern recognition receptor signaling pathway |
| positive regulation of interleukin-12 production |
| membrane protein proteolysis |
| protein K63-linked ubiquitination |
| osteoclast differentiation |
| bone remodeling |
| positive regulation of T cell mediated immunity |
| regulation of transcription regulatory region DNA binding |
| cytoplasmic side of plasma membrane |
| regulation of interleukin-2 production |
| positive regulation of cytokine production involved in immune response |
| regulation of interleukin-12 production |
| positive regulation of myeloid leukocyte differentiation |
| positive regulation of DNA binding |
| regulation of immunoglobulin production |
| regulation of osteoclast differentiation |
| protein autoubiquitination |
| positive regulation of cytokine biosynthetic process |
| I-kappaB kinase/NF-kappaB signaling |
| regulation of T cell mediated immunity |
| positive regulation of JUN kinase activity |
| positive regulation of NIK/NF-kappaB signaling |
| NIK/NF-kappaB signaling |
| lipid droplet |
| JNK cascade |
| odontogenesis of dentin-containing tooth |
| regulation of cytokine production involved in immune response |
| positive regulation of smooth muscle cell proliferation |
| regulation of JUN kinase activity |
| neural tube closure |
| positive regulation of myeloid cell differentiation |
| tube closure |
| positive regulation of interleukin-6 production |
| positive regulation of T cell proliferation |
| interleukin-1-mediated signaling pathway |
| positive regulation of production of molecular mediator of immune response |
| primary neural tube formation |
| antigen processing and presentation of exogenous peptide antigen via MHC class II |
| toll-like receptor signaling pathway |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| antigen processing and presentation of peptide antigen via MHC class II |
| tissue remodeling |
| stress-activated MAPK cascade |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| regulation of cytokine biosynthetic process |
| neural tube formation |
| protein N-terminus binding |
| regulation of NIK/NF-kappaB signaling |
| myeloid leukocyte differentiation |
| histone deacetylase binding |
| stimulatory C-type lectin receptor signaling pathway |
| regulation of myeloid leukocyte differentiation |
| innate immune response activating cell surface receptor signaling pathway |
| positive regulation of protein ubiquitination |
| odontogenesis |
| embryonic epithelial tube formation |
| regulation of DNA binding |
| pattern recognition receptor signaling pathway |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| epithelial tube formation |
| positive regulation of leukocyte mediated immunity |
| regulation of smooth muscle cell proliferation |
| positive regulation of protein modification by small protein conjugation or removal |
| cell cortex |
| positive regulation of leukocyte proliferation |
| positive regulation of JNK cascade |
| regulation of interleukin-6 production |
| regulation of production of molecular mediator of immune response |
| stress-activated protein kinase signaling cascade |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| morphogenesis of embryonic epithelium |
| positive regulation of leukocyte differentiation |
| tube formation |
| regulation of lymphocyte mediated immunity |
| positive regulation of NF-kappaB transcription factor activity |
| activation of MAPK activity |
| regulation of T cell proliferation |
| neural tube development |
| regulation of adaptive immune response |
| intracellular receptor signaling pathway |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| Fc-epsilon receptor signaling pathway |
| cellular response to interleukin-1 |
| T cell receptor signaling pathway |
| antigen processing and presentation of exogenous peptide antigen |
| positive regulation of binding |
| antigen processing and presentation of exogenous antigen |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| cellular response to lipopolysaccharide |
| regulation of JNK cascade |
| positive regulation of hemopoiesis |
| antigen processing and presentation of peptide antigen |
| tissue homeostasis |
| cellular response to molecule of bacterial origin |
| response to interleukin-1 |
| regulation of protein ubiquitination |
| positive regulation of T cell activation |
| regulation of leukocyte mediated immunity |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| endosome membrane |
| cellular response to biotic stimulus |
| positive regulation of leukocyte cell-cell adhesion |
| antigen processing and presentation |
| positive regulation of immune effector process |
| myeloid cell differentiation |
| ubiquitin protein ligase activity |
| regulation of leukocyte proliferation |
| regulation of myeloid cell differentiation |
| regulation of protein modification by small protein conjugation or removal |
| regulation of stress-activated MAPK cascade |
| innate immune response-activating signal transduction |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of stress-activated protein kinase signaling cascade |
| Fc receptor signaling pathway |
| ubiquitin-protein transferase activity |
| positive regulation of cell-cell adhesion |
| activation of innate immune response |
| positive regulation of MAP kinase activity |
| ossification |
| positive regulation of DNA-binding transcription factor activity |
| regulation of leukocyte differentiation |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| protein deubiquitination |
| ubiquitin protein ligase binding |
| antigen receptor-mediated signaling pathway |
| regulation of leukocyte cell-cell adhesion |
| protein modification by small protein removal |
| protein polyubiquitination |
| epithelial tube morphogenesis |
| response to lipopolysaccharide |
| regulation of T cell activation |
| multicellular organismal homeostasis |
| response to molecule of bacterial origin |
| activation of protein kinase activity |
| leukocyte differentiation |
| positive regulation of protein serine/threonine kinase activity |
| anatomical structure homeostasis |
| positive regulation of innate immune response |
| regulation of MAP kinase activity |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| MAPK cascade |
| in utero embryonic development |
| regulation of binding |
| signal transduction by protein phosphorylation |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| regulation of DNA-binding transcription factor activity |
| morphogenesis of an epithelium |
| immune response-activating cell surface receptor signaling pathway |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of innate immune response |
| protein kinase binding |
| regulation of protein secretion |
| regulation of immune effector process |
| positive regulation of defense response |
| immune response-regulating cell surface receptor signaling pathway |
| regulation of peptide secretion |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| cellular response to lipid |
| regulation of response to biotic stimulus |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| hemopoiesis |
| immune response-activating signal transduction |
| tissue morphogenesis |
| embryonic morphogenesis |
| positive regulation of kinase activity |
| myeloid leukocyte activation |
| protein-containing complex |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| adaptive immune response |
| activation of immune response |
| chordate embryonic development |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| immune system development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| protein ubiquitination |
| response to bacterium |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| positive regulation of cell death |
| regulation of protein transport |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| protein modification by small protein conjugation |
| cellular response to DNA damage stimulus |
| regulation of multi-organism process |
| regulation of protein kinase activity |
| regulation of secretion |
| zinc ion binding |
| tube development |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of immune response |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| leukocyte activation |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| protein phosphorylation |
| embryo development |
| regulation of transferase activity |
| protein modification by small protein conjugation or removal |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| identical protein binding |
| cell activation |
| regulation of response to external stimulus |
| response to cytokine |
| epithelium development |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| proteolysis |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| PFI-2 4μM R05 exp239 | -1.7 |
| BI-2536 0.02μM R03 exp96 | 1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18578
- Expression level (log2 read counts): 4.71
Expression Distribution
TRAF6 Expression in NALM6 Cells: 4.71
