TRIM41

Entrez Summary: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C. {ECO:0000269|PubMed:17893151}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular response to muramyl dipeptide
response to muramyl dipeptide
transferase activity
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
cellular response to biotic stimulus
nuclear body
response to lipopolysaccharide
cellular response to peptide
response to molecule of bacterial origin
cellular response to drug
response to peptide
cellular response to lipid
cellular response to organonitrogen compound
cellular response to nitrogen compound
protein ubiquitination
response to bacterium
protein modification by small protein conjugation
zinc ion binding
response to lipid
nucleolus
protein modification by small protein conjugation or removal
response to organonitrogen compound
response to drug
cellular response to oxygen-containing compound
identical protein binding
response to nitrogen compound
cellular response to endogenous stimulus
response to other organism
response to external biotic stimulus
response to biotic stimulus
response to endogenous stimulus
response to oxygen-containing compound