TRIM72

Gene Information

Official Symbol: TRIM72
Official Name: tripartite motif containing 72
Aliases and Previous Symbols: N/A
Entrez ID: 493829
UniProt: Q6ZMU5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6609
Expression level (log2 read counts): 4.48

Expression Distribution

zf-C3HC4
zf-B box
SPRY

negative regulation of insulin-like growth factor receptor signaling pathway
plasma membrane repair
negative regulation of myotube differentiation
regulation of insulin-like growth factor receptor signaling pathway
ubiquitin conjugating enzyme binding
negative regulation of insulin receptor signaling pathway
negative regulation of cellular response to insulin stimulus
negative regulation of striated muscle cell differentiation
negative regulation of muscle cell differentiation
regulation of myotube differentiation
phosphatidylserine binding
regulation of insulin receptor signaling pathway
regulation of cellular response to insulin stimulus
plasma membrane organization
sarcolemma
regulation of striated muscle cell differentiation
cytoplasmic vesicle membrane
regulation of muscle cell differentiation
ubiquitin protein ligase activity
muscle contraction
muscle organ development
muscle system process
proteasome-mediated ubiquitin-dependent protein catabolic process
protein homooligomerization
proteasomal protein catabolic process
endomembrane system organization
muscle structure development
wound healing
protein complex oligomerization
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
response to wounding
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
negative regulation of cell differentiation
protein modification by small protein conjugation
exocytosis