TRPC1

Gene Information

Official Symbol: TRPC1
Official Name: transient receptor potential cation channel subfamily C member 1
Aliases and Previous Symbols: N/A
Entrez ID: 7220
UniProt: P48995
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. {ECO:0000269|PubMed:15016832}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Geldanamycin 0.01μM R05 exp235	-1.88
Glyphosate 1000μM R06 exp283	-1.81
Aphidicolin 0.04μM R06 exp263	-1.75
Genistein 15μM R07 exp360	1.81
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.97
Rotenone 20μM R00 exp34	2.32

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5395
Expression level (log2 read counts): 1.58

Expression Distribution

Ion trans
TRP 2
Ank 2

cation channel complex
store-operated calcium channel activity
manganese ion transport
inositol 1,4,5 trisphosphate binding
melanin biosynthetic process
melanin metabolic process
cation channel activity
secondary metabolite biosynthetic process
phenol-containing compound biosynthetic process
positive regulation of release of sequestered calcium ion into cytosol
pigment biosynthetic process
calcium channel activity
positive regulation of calcium ion transport into cytosol
secondary metabolic process
pigment metabolic process
regulation of cardiac conduction
positive regulation of calcium ion transmembrane transport
regulation of release of sequestered calcium ion into cytosol
phenol-containing compound metabolic process
regulation of calcium ion transport into cytosol
transition metal ion transport
positive regulation of calcium ion transport
regulation of sequestering of calcium ion
positive regulation of cation transmembrane transport
regulation of calcium ion transmembrane transport
response to calcium ion
positive regulation of ion transmembrane transport
organic hydroxy compound biosynthetic process
calcium ion transmembrane transport
positive regulation of transmembrane transport
receptor complex
regulation of heart contraction
regulation of calcium ion transport
calcium ion transport
positive regulation of ion transport
positive regulation of cytosolic calcium ion concentration
regulation of blood circulation
divalent metal ion transport
divalent inorganic cation transport
regulation of cytosolic calcium ion concentration