TRPV2

Official Symbol: TRPV2
Official Name: transient receptor potential cation channel subfamily V member 2
Aliases and Previous Symbols: N/A
Entrez ID: 51393
UniProt: Q9Y5S1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. {ECO:0000269|PubMed:10201375}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Cycloheximide 0.02μM R00 exp14	-1.74
HMS-I1 10μM R06 exp256	1.85

growth cone membrane
ion transmembrane transporter activity
cation channel activity
positive regulation of calcium ion import
ion channel activity
axonal growth cone
regulation of calcium ion import
positive regulation of axon extension
calcium channel activity
cell body
positive regulation of axonogenesis
regulation of axon extension
positive regulation of cold-induced thermogenesis
melanosome
response to heat
regulation of extent of cell growth
positive regulation of calcium ion transport
regulation of cold-induced thermogenesis
positive regulation of cell morphogenesis involved in differentiation
positive regulation of cell growth
positive regulation of developmental growth
response to temperature stimulus
regulation of cell size
regulation of axonogenesis
calcium ion transmembrane transport
regulation of calcium ion transport
calcium ion transport
positive regulation of growth
positive regulation of ion transport
positive regulation of neuron projection development
divalent metal ion transport
divalent inorganic cation transport
regulation of cell morphogenesis involved in differentiation
regulation of developmental growth
positive regulation of neuron differentiation
regulation of cellular component size
positive regulation of cell projection organization
regulation of metal ion transport
regulation of cell growth
positive regulation of neurogenesis