TSSK4

Entrez Summary: N/A
UniProt Summary: May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling. {ECO:0000250, ECO:0000269|PubMed:15964553}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

peptidyl-threonine autophosphorylation
positive regulation of CREB transcription factor activity
sperm flagellum
peptidyl-threonine phosphorylation
acrosomal vesicle
peptidyl-threonine modification
spermatid development
spermatid differentiation
fertilization
peptidyl-serine phosphorylation
protein autophosphorylation
peptidyl-serine modification
magnesium ion binding
germ cell development
positive regulation of DNA-binding transcription factor activity
protein-containing complex binding
cellular process involved in reproduction in multicellular organism
protein serine/threonine kinase activity
regulation of DNA-binding transcription factor activity
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
protein homodimerization activity
peptidyl-amino acid modification
protein phosphorylation
multi-organism reproductive process
phosphorylation
reproductive process
reproduction
ATP binding
cell development
intracellular signal transduction
positive regulation of molecular function