TXNL4A
Gene Information
- Official Symbol: TXNL4A
- Official Name: thioredoxin like 4A
- Aliases and Previous Symbols: N/A
- Entrez ID: 10907
- UniProt: P83876
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. This protein contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].
- UniProt Summary: Essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly. {ECO:0000269|PubMed:10610776}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 53
- Expression level (log2 read counts): 6.24
TXNL4A Expression in NALM6 Cells: 6.24
