UBXN8

Entrez Summary: p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013].
UniProt Summary: Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction. {ECO:0000269|PubMed:21949850}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

ubiquitin-dependent ERAD pathway
ERAD pathway
integral component of endoplasmic reticulum membrane
single fertilization
fertilization
response to endoplasmic reticulum stress
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
sexual reproduction
nucleolus
cellular macromolecule catabolic process
multi-organism reproductive process
response to organonitrogen compound
endoplasmic reticulum
macromolecule catabolic process
organonitrogen compound catabolic process
response to nitrogen compound
proteolysis
reproductive process
reproduction
cellular response to stress
organic substance catabolic process
cellular catabolic process