UCK2

Gene Information

Official Symbol: UCK2
Official Name: uridine-cytidine kinase 2
Aliases and Previous Symbols: N/A
Entrez ID: 7371
UniProt: Q9BZX2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
AICAR 240μM R05 exp211	-4.28
AICAR 240μM R03 exp116	-4.05
HMS-I2 10μM R06 exp288	-2.79
CyclicAMP 200μM R08 exp475	-2.64
HMS-I2 5μM R06 exp287	-2.29
Dinaciclib 0.007μM R07 exp355	2.13
5-Fluorouracil 2μM R00 exp1	2.91
Zebularine 20μM R07 exp423	4.72
5-Fluorouracil 20μM R00 exp2	7.25
5-Azacytidine 2μM R07 exp330	8.49

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12528
Expression level (log2 read counts): 6.84

Expression Distribution

CTP salvage
uridine kinase activity
pyrimidine ribonucleotide salvage
pyrimidine nucleotide salvage
UMP salvage
pyrimidine ribonucleoside monophosphate metabolic process
UMP metabolic process
pyrimidine ribonucleoside monophosphate biosynthetic process
UMP biosynthetic process
pyrimidine-containing compound salvage
pyrimidine nucleoside salvage
nucleotide salvage
CTP biosynthetic process
CTP metabolic process
pyrimidine ribonucleoside triphosphate biosynthetic process
pyrimidine nucleoside biosynthetic process
nucleoside salvage
pyrimidine nucleoside monophosphate biosynthetic process
pyrimidine ribonucleoside triphosphate metabolic process
pyrimidine nucleoside monophosphate metabolic process
pyrimidine nucleoside triphosphate biosynthetic process
pyrimidine ribonucleotide biosynthetic process
pyrimidine nucleoside triphosphate metabolic process
pyrimidine ribonucleotide metabolic process
ribonucleoside monophosphate biosynthetic process
cellular metabolic compound salvage
pyrimidine nucleoside metabolic process
nucleoside biosynthetic process
glycosyl compound biosynthetic process
nucleoside monophosphate biosynthetic process
pyrimidine nucleotide biosynthetic process
ribonucleoside triphosphate biosynthetic process
ribonucleoside monophosphate metabolic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate metabolic process
nucleoside monophosphate metabolic process
kinase activity
nucleoside triphosphate metabolic process