UGT2A1

Entrez Summary: N/A
UniProt Summary: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium. {ECO:0000269|PubMed:19858781}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
2-Methoxyestradiol 0.2μM R01 exp40	2.07
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.12

UDPGT
Glyco tran 28 C

cellular glucuronidation
UDP-glycosyltransferase activity
glucuronate metabolic process
uronic acid metabolic process
glucuronosyltransferase activity
monosaccharide metabolic process
sensory perception of smell
carbohydrate metabolic process
detection of chemical stimulus
monocarboxylic acid metabolic process
sensory perception of chemical stimulus
intracellular membrane-bounded organelle
detection of stimulus
carboxylic acid metabolic process
sensory perception
oxoacid metabolic process
organic acid metabolic process
nervous system process
small molecule metabolic process
system process