VILL

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CCT251545 20μM R07 exp326	-1.91
All-trans-Retinoic-Acid 40μM R07 exp334	-1.89
Aminopterin 0.005μM R07 exp335	1.74

VHP
Gelsolin

actin filament capping
negative regulation of actin filament depolymerization
regulation of actin filament depolymerization
negative regulation of actin filament polymerization
negative regulation of protein depolymerization
negative regulation of protein polymerization
negative regulation of protein complex disassembly
regulation of protein depolymerization
structural constituent of cytoskeleton
regulation of protein complex disassembly
negative regulation of supramolecular fiber organization
negative regulation of protein complex assembly
negative regulation of cytoskeleton organization
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
actin filament binding
actin cytoskeleton
regulation of protein polymerization
regulation of actin filament organization
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
negative regulation of organelle organization
regulation of cellular component size
regulation of actin filament-based process
regulation of protein complex assembly
regulation of anatomical structure size
regulation of cytoskeleton organization
negative regulation of cellular component organization
regulation of cellular component biogenesis
cytoskeleton organization
regulation of organelle organization