WDR55

Entrez Summary: N/A
UniProt Summary: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Adefovir 20μM R07 exp332	-2.13
VER-155008 3.9μM R06 exp301	-2.03
Mdivi-1 15μM R05 exp217	-1.89
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.86
Heregulin-B 44ng/ml R08 exp486	-1.83
Arsenate 40μM R06 exp264	-1.8
Wiskostatin 3μM R07 exp422	-1.73
Temozolomide 200μM R04 exp189	1.82

Global Fraction of Cell Lines Where Essential: 646/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	27/28
bone	22/26
breast	26/33
central nervous system	53/56
cervix	4/4
colorectal	15/17
esophagus	11/13
fibroblast	1/1
gastric	12/16
kidney	16/21
liver	17/20
lung	66/75
lymphocyte	16/16
ovary	24/26
pancreas	20/24
peripheral nervous system	14/16
plasma cell	13/15
prostate	0/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	26/29
uterus	5/5

Expression Distribution

rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
cellular component
ribonucleoprotein complex biogenesis
ncRNA metabolic process
molecular function
nucleolus
RNA processing
RNA metabolic process
gene expression