WDR91

Entrez Summary: N/A
UniProt Summary: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity). {ECO:0000250|UniProtKB:Q7TMQ7, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Vemurafenib 6.6μM R08 exp434	-2.22
Vemurafenib 6.6μM R02 exp89	-1.98
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.98

phosphatidylinositol 3-kinase regulator activity
extrinsic component of endosome membrane
early endosome to late endosome transport
vesicle-mediated transport between endosomal compartments
regulation of phosphatidylinositol 3-kinase activity
regulation of lipid kinase activity
regulation of phospholipid metabolic process
late endosome membrane
cytosolic transport
early endosome membrane
regulation of cellular protein catabolic process
regulation of protein catabolic process
regulation of lipid metabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
regulation of cellular catabolic process
regulation of kinase activity
cellular macromolecule catabolic process
regulation of transferase activity
regulation of catabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
intracellular transport
regulation of phosphorylation
organic substance catabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
cellular catabolic process
establishment of localization in cell
vesicle-mediated transport