WRNIP1

Entrez Summary: N/A
UniProt Summary: Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS. {ECO:0000269|PubMed:15670210, ECO:0000269|PubMed:29053956}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of DNA-dependent DNA replication initiation
single-stranded DNA helicase activity
enzyme activator activity
DNA synthesis involved in DNA repair
regulation of DNA-dependent DNA replication
regulation of DNA replication
nuclear chromosome, telomeric region
DNA biosynthetic process
DNA duplex unwinding
DNA geometric change
DNA-dependent DNA replication
regulation of DNA repair
DNA replication
regulation of response to DNA damage stimulus
ATPase activity
DNA conformation change
regulation of DNA metabolic process
DNA repair
perinuclear region of cytoplasm
regulation of cellular response to stress
DNA metabolic process
innate immune response
cellular response to DNA damage stimulus
defense response to other organism
chromosome organization
identical protein binding
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
response to other organism
organic cyclic compound biosynthetic process
response to external biotic stimulus
response to biotic stimulus
defense response
positive regulation of catalytic activity
DNA binding
regulation of response to stress
ATP binding
cellular nitrogen compound biosynthetic process
cellular response to stress