WWC3

Entrez Summary: This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MKC9989 10μM R03 exp133	-1.9
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.84
5-Azacytidine 2μM R07 exp330	-1.81
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.74
Phenformin 20μM R05 exp212	2.08

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

negative regulation of hippo signaling
regulation of hippo signaling
negative regulation of organ growth
molecular adaptor activity
kinase binding
regulation of organ growth
negative regulation of developmental growth
negative regulation of growth
regulation of developmental growth
negative regulation of intracellular signal transduction
regulation of growth
negative regulation of transcription by RNA polymerase II
negative regulation of developmental process
negative regulation of transcription, DNA-templated
negative regulation of multicellular organismal process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of signal transduction
negative regulation of RNA metabolic process
negative regulation of cell communication
negative regulation of signaling
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of response to stimulus
negative regulation of gene expression
regulation of intracellular signal transduction