YWHAH
Gene Information
- Official Symbol: YWHAH
- Official Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
- Aliases and Previous Symbols: N/A
- Entrez ID: 7533
- UniProt: Q04917
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}.
Pfam Domains GO Terms
Pfam Domains
| 14-3-3 |
GO Terms
| glucocorticoid catabolic process |
| glucocorticoid receptor signaling pathway |
| corticosteroid receptor signaling pathway |
| glucocorticoid metabolic process |
| negative regulation of dendrite morphogenesis |
| glucocorticoid receptor binding |
| hormone catabolic process |
| insulin-like growth factor receptor binding |
| positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| steroid catabolic process |
| negative regulation of dendrite development |
| membrane depolarization during action potential |
| sodium channel regulator activity |
| positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| substantia nigra development |
| regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| intercalated disc |
| membrane depolarization |
| regulation of sodium ion transmembrane transporter activity |
| positive regulation of establishment of protein localization to mitochondrion |
| neural nucleus development |
| regulation of sodium ion transmembrane transport |
| intracellular steroid hormone receptor signaling pathway |
| regulation of mitochondrial membrane permeability |
| regulation of establishment of protein localization to mitochondrion |
| regulation of membrane permeability |
| midbrain development |
| regulation of sodium ion transport |
| regulation of dendrite morphogenesis |
| action potential |
| negative regulation of cell morphogenesis involved in differentiation |
| positive regulation of mitochondrion organization |
| steroid hormone mediated signaling pathway |
| positive regulation of protein localization to membrane |
| ion channel binding |
| mitochondrial membrane organization |
| regulation of dendrite development |
| negative regulation of neuron projection development |
| intracellular receptor signaling pathway |
| hormone-mediated signaling pathway |
| positive regulation of apoptotic signaling pathway |
| regulation of mitochondrion organization |
| negative regulation of cell projection organization |
| cellular response to steroid hormone stimulus |
| regulation of synaptic plasticity |
| regulation of protein localization to membrane |
| hormone metabolic process |
| mitochondrial transport |
| negative regulation of neuron differentiation |
| protein domain specific binding |
| regulation of ion transmembrane transporter activity |
| steroid metabolic process |
| regulation of transmembrane transporter activity |
| actin binding |
| regulation of transporter activity |
| negative regulation of neurogenesis |
| lipid catabolic process |
| regulation of cell morphogenesis involved in differentiation |
| negative regulation of nervous system development |
| positive regulation of cellular protein localization |
| response to steroid hormone |
| negative regulation of cell development |
| regulation of cation transmembrane transport |
| enzyme binding |
| regulation of metal ion transport |
| regulation of apoptotic signaling pathway |
| regulation of membrane potential |
| modulation of chemical synaptic transmission |
| mitochondrion organization |
| regulation of trans-synaptic signaling |
| positive regulation of establishment of protein localization |
| regulation of ion transmembrane transport |
| organic cyclic compound catabolic process |
| protein heterodimerization activity |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| cellular response to lipid |
| regulation of hormone levels |
| regulation of cellular protein localization |
| cellular response to organic cyclic compound |
| regulation of transmembrane transport |
| cellular response to hormone stimulus |
| positive regulation of organelle organization |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| regulation of neuron differentiation |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| regulation of ion transport |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| brain development |
| regulation of establishment of protein localization |
| head development |
| regulation of neurogenesis |
| response to lipid |
| membrane organization |
| response to hormone |
| regulation of cellular localization |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| central nervous system development |
| positive regulation of transport |
| intracellular protein transport |
| regulation of protein localization |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| mitochondrion |
| regulation of organelle organization |
| response to endogenous stimulus |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of RNA metabolic process |
| organic substance catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| TRAIL 5ng/ml R00 exp35 | -1.71 |
| LLY-283 2.6μM R06 exp290 | 1.7 |
| Nocodazole 0.1μM R03 exp94 | 2.06 |
| BI-6727 0.0125μM R03 exp97 | 2.07 |
| BI-2536 0.0042μM R03 exp95 | 2.17 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.409 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11945
- Expression level (log2 read counts): 6.89
Expression Distribution
YWHAH Expression in NALM6 Cells: 6.89
