ZC3H3

Entrez Summary: N/A
UniProt Summary: Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double- stranded DNA in vitro. Involved in RNA cleavage (By similarity). {ECO:0000250|UniProtKB:Q8CHP0, ECO:0000269|PubMed:19364924}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
LJH685 5μM R02 exp73	1.75
Dihydrosphingosine 8μM R08 exp476	2.03

positive regulation of activin receptor signaling pathway
mRNA cleavage and polyadenylation specificity factor complex
regulation of mRNA polyadenylation
R-SMAD binding
regulation of activin receptor signaling pathway
regulation of mRNA 3-end processing
mRNA 3-end processing
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
RNA 3-end processing
regulation of mRNA processing
mRNA transport
nucleic acid transport
RNA transport
establishment of RNA localization
RNA localization
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
nucleobase-containing compound transport
regulation of mRNA metabolic process
mRNA processing
mRNA metabolic process
molecular function
RNA processing
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of signal transduction
RNA metabolic process
positive regulation of cell communication
positive regulation of signaling
nitrogen compound transport
gene expression