ZDHHC9

Entrez Summary: This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010].
UniProt Summary: The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. {ECO:0000269|PubMed:16000296}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Ras palmitoyltransferase activity
palmitoyltransferase complex
intrinsic component of Golgi membrane
palmitoyltransferase activity
peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
peptidyl-L-cysteine S-palmitoylation
protein-cysteine S-palmitoyltransferase activity
protein palmitoylation
peptidyl-cysteine modification
protein lipidation
lipoprotein biosynthetic process
lipoprotein metabolic process
protein targeting to membrane
protein acylation
establishment of protein localization to membrane
protein targeting
protein localization to membrane
peptidyl-amino acid modification
endoplasmic reticulum membrane
Golgi apparatus
intracellular protein transport
endoplasmic reticulum
organonitrogen compound biosynthetic process
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
establishment of localization in cell
nitrogen compound transport