ZEB2
Gene Information
- Official Symbol: ZEB2
- Official Name: zinc finger E-box binding homeobox 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 9839
- UniProt: O60315
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010].
- UniProt Summary: Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E- cadherin. {ECO:0000269|PubMed:16061479}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| positive regulation of lens fiber cell differentiation |
| mammillary body development |
| regulation of melanosome organization |
| melanocyte migration |
| mammillary axonal complex development |
| regulation of lens fiber cell differentiation |
| positive regulation of melanocyte differentiation |
| positive regulation of melanin biosynthetic process |
| regulation of melanocyte differentiation |
| corpus callosum morphogenesis |
| positive regulation of secondary metabolite biosynthetic process |
| corticospinal tract morphogenesis |
| positive regulation of pigment cell differentiation |
| regulation of pigment cell differentiation |
| phosphatase regulator activity |
| collateral sprouting |
| positive regulation of developmental pigmentation |
| regulation of melanin biosynthetic process |
| regulation of secondary metabolite biosynthetic process |
| regulation of secondary metabolic process |
| regulation of developmental pigmentation |
| corpus callosum development |
| R-SMAD binding |
| central nervous system projection neuron axonogenesis |
| cell proliferation in forebrain |
| central nervous system neuron axonogenesis |
| developmental pigmentation |
| neural crest cell migration |
| positive regulation of epithelial cell differentiation |
| somitogenesis |
| positive regulation of JUN kinase activity |
| neural precursor cell proliferation |
| diencephalon development |
| neural crest cell development |
| central nervous system neuron development |
| hippocampus development |
| somite development |
| mesenchymal cell development |
| epithelial cell migration |
| stem cell development |
| positive regulation of axonogenesis |
| epithelium migration |
| regulation of JUN kinase activity |
| developmental cell growth |
| neural crest cell differentiation |
| cell growth |
| neural tube closure |
| tube closure |
| pigmentation |
| tissue migration |
| segmentation |
| primary neural tube formation |
| neural tube formation |
| limbic system development |
| developmental growth involved in morphogenesis |
| embryonic epithelial tube formation |
| epithelial tube formation |
| positive regulation of JNK cascade |
| regulation of epithelial cell differentiation |
| morphogenesis of embryonic epithelium |
| tube formation |
| positive regulation of cell morphogenesis involved in differentiation |
| mesenchymal cell differentiation |
| stem cell differentiation |
| neural tube development |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| ameboidal-type cell migration |
| pallium development |
| positive regulation of Wnt signaling pathway |
| central nervous system neuron differentiation |
| regulation of axonogenesis |
| regulation of JNK cascade |
| anterior/posterior pattern specification |
| mesenchyme development |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| nuclear chromatin |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| telencephalon development |
| positive regulation of MAP kinase activity |
| positive regulation of neuron projection development |
| regulation of cell morphogenesis involved in differentiation |
| epithelial tube morphogenesis |
| regionalization |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| regulation of Wnt signaling pathway |
| positive regulation of neuron differentiation |
| axonogenesis |
| positive regulation of cell projection organization |
| forebrain development |
| developmental growth |
| growth |
| axon development |
| sequence-specific DNA binding |
| cell morphogenesis involved in neuron differentiation |
| morphogenesis of an epithelium |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| positive regulation of neurogenesis |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| cell part morphogenesis |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| cell population proliferation |
| cell morphogenesis involved in differentiation |
| tissue morphogenesis |
| embryonic morphogenesis |
| positive regulation of kinase activity |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| cell morphogenesis |
| regulation of cellular response to stress |
| brain development |
| regulation of MAPK cascade |
| head development |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| tube development |
| nucleolus |
| negative regulation of transcription by RNA polymerase II |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| regulation of nervous system development |
| regulation of cell development |
| cell migration |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| embryo development |
| central nervous system development |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| epithelium development |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of organelle organization |
| locomotion |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Radicicol 0.16μM R05 exp242 | -2.08 |
| VER-155008 3.9μM R06 exp301 | -2.06 |
| MK-1775 0.32μM R02 exp75 | -1.92 |
| Selumetinib 20μM R02 exp81 | -1.84 |
| Nutlin-3A 1.6μM R06 exp294 | 1.71 |
| S-DABN 8μM R03 exp112 | 1.77 |
| Doxorubicin 0.02μM R08 exp478 | 1.86 |
| BI-6727 0.04μM R03 exp98 | 1.92 |
| CCT251545 20μM R07 exp326 | 3.49 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 25/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 6/28 |
| bone | 1/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 5/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1109
- Expression level (log2 read counts): 7.33
Expression Distribution
ZEB2 Expression in NALM6 Cells: 7.33
