ZHX2

Entrez Summary: The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008].
UniProt Summary: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. {ECO:0000269|PubMed:12741956}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 2μM R00 exp25	-2.11
Etoposide 10μM R00 exp20	-1.98
Arsenate 40μM R06 exp264	-1.83
Rotenone 2μM R00 exp33	-1.81
UM0131023 0.05μM R05 exp248	1.87
Vemurafenib 6.6μM R08 exp434	1.9
CB-839 10μM R05 exp224	1.93
Ethanol 0.01 R05 exp234	2.21
Lead acetate 2000μM R08 exp498 no dilution day6	2.28

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

retinal bipolar neuron differentiation
retina morphogenesis in camera-type eye
neural retina development
somatic stem cell population maintenance
camera-type eye morphogenesis
stem cell population maintenance
maintenance of cell number
retina development in camera-type eye
eye morphogenesis
mRNA catabolic process
negative regulation of neuron differentiation
transcription corepressor activity
RNA catabolic process
sensory organ morphogenesis
negative regulation of neurogenesis
negative regulation of nervous system development
camera-type eye development
negative regulation of cell development
eye development
visual system development
sensory system development
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
protein heterodimerization activity
sensory organ development
regulation of neuron differentiation
DNA-binding transcription factor activity
mRNA metabolic process
negative regulation of cell differentiation
regulation of neurogenesis
negative regulation of transcription by RNA polymerase II
protein homodimerization activity
cellular macromolecule catabolic process
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
animal organ morphogenesis