ABCA3
Gene Information
- Official Symbol: ABCA3
- Official Name: ATP binding cassette subfamily A member 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 21
- UniProt: Q99758
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008].
- UniProt Summary: Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4702
- Expression level (log2 read counts): 1.84
ABCA3 Expression in NALM6 Cells: 1.84
