ACAD11

Entrez Summary: This gene encodes an acyl-CoA dehydrogenase enzyme with a preference for carbon chain lengths between 20 and 26. Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene. [provided by RefSeq, Aug 2015].
UniProt Summary: Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. {ECO:0000269|PubMed:21237683}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.75
Nicotine 3000μM R08 exp510	1.84
Rucaparib 6.5μM R08 exp520	1.93

medium-chain-acyl-CoA dehydrogenase activity
very-long-chain-acyl-CoA dehydrogenase activity
long-chain-acyl-CoA dehydrogenase activity
acyl-CoA dehydrogenase activity
fatty acid beta-oxidation using acyl-CoA dehydrogenase
flavin adenine dinucleotide binding
fatty acid beta-oxidation
fatty acid oxidation
lipid oxidation
fatty acid catabolic process
mitochondrial membrane
peroxisome
monocarboxylic acid catabolic process
cellular lipid catabolic process
lipid modification
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
fatty acid metabolic process
mitochondrial inner membrane
small molecule catabolic process
monocarboxylic acid metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process