ACER1

Entrez Summary: N/A
UniProt Summary: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Mubritinib 0.2μM R01 exp48	-1.81
NFN1 0.1μM R01 exp49	-1.71
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.24

response to alkaline pH
dihydroceramidase activity
ceramidase activity
N-acylsphingosine amidohydrolase activity
sebaceous gland development
sphingosine biosynthetic process
sphingoid biosynthetic process
sphingosine metabolic process
sphingoid metabolic process
diol biosynthetic process
ceramide catabolic process
diol metabolic process
regulation of water loss via skin
sphingolipid catabolic process
membrane lipid catabolic process
response to pH
polyol biosynthetic process
multicellular organismal water homeostasis
water homeostasis
ceramide metabolic process
cellular response to calcium ion
sphingolipid biosynthetic process
polyol metabolic process
alcohol biosynthetic process
membrane lipid biosynthetic process
response to calcium ion
sphingolipid metabolic process
organic hydroxy compound biosynthetic process
cellular response to metal ion
ammonium ion metabolic process
cellular lipid catabolic process
membrane lipid metabolic process
cellular response to inorganic substance
keratinocyte differentiation
lipid catabolic process
epidermal cell differentiation
alcohol metabolic process
multicellular organismal homeostasis
response to metal ion
skin development