ACSM2A

Entrez Summary: This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event. [provided by RefSeq, May 2017].
UniProt Summary: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

medium-chain fatty-acyl-CoA metabolic process
fatty-acyl-CoA synthase activity
fatty acid ligase activity
butyrate-CoA ligase activity
acyl-CoA ligase activity
acylglycerol homeostasis
triglyceride homeostasis
fatty-acyl-CoA metabolic process
acyl-CoA metabolic process
thioester metabolic process
fatty acid biosynthetic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
lipid homeostasis
fatty acid derivative metabolic process
glucose homeostasis
monocarboxylic acid biosynthetic process
carbohydrate homeostasis
coenzyme metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
purine ribonucleotide metabolic process
fatty acid metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
mitochondrial matrix
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
monocarboxylic acid metabolic process
nucleobase-containing small molecule metabolic process
lipid biosynthetic process
small molecule biosynthetic process
cellular amide metabolic process
organophosphate metabolic process
carboxylic acid metabolic process