ACSS1
Gene Information
- Official Symbol: ACSS1
- Official Name: acyl-CoA synthetase short chain family member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 84532
- UniProt: Q9NUB1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| AMP-binding |
| DUF3448 |
GO Terms
| propionate biosynthetic process |
| acetate biosynthetic process |
| acetyl-CoA biosynthetic process from acetate |
| acetate metabolic process |
| acetate-CoA ligase activity |
| short-chain fatty acid biosynthetic process |
| propionate metabolic process |
| ethanol oxidation |
| antibiotic biosynthetic process |
| AMP binding |
| acetyl-CoA biosynthetic process |
| short-chain fatty acid metabolic process |
| ethanol metabolic process |
| acetyl-CoA metabolic process |
| thioester biosynthetic process |
| acyl-CoA biosynthetic process |
| purine nucleoside bisphosphate biosynthetic process |
| nucleoside bisphosphate biosynthetic process |
| ribonucleoside bisphosphate biosynthetic process |
| primary alcohol metabolic process |
| acyl-CoA metabolic process |
| thioester metabolic process |
| antibiotic metabolic process |
| fatty acid biosynthetic process |
| ribonucleoside bisphosphate metabolic process |
| nucleoside bisphosphate metabolic process |
| purine nucleoside bisphosphate metabolic process |
| coenzyme biosynthetic process |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| sulfur compound biosynthetic process |
| monocarboxylic acid biosynthetic process |
| cofactor biosynthetic process |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| coenzyme metabolic process |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| purine ribonucleotide metabolic process |
| alcohol metabolic process |
| fatty acid metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| sulfur compound metabolic process |
| purine-containing compound metabolic process |
| mitochondrial matrix |
| generation of precursor metabolites and energy |
| cofactor metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organic hydroxy compound metabolic process |
| drug metabolic process |
| amide biosynthetic process |
| monocarboxylic acid metabolic process |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| carbohydrate derivative biosynthetic process |
| cellular amide metabolic process |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| cellular lipid metabolic process |
| oxidation-reduction process |
| oxoacid metabolic process |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| lipid metabolic process |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| ATP binding |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| HMS-I1 10μM R06 exp256 | -1.84 |
| Hydroxyurea 15μM R06 exp289 | -1.7 |
| Rifampicin 30μM R08 exp430 | 2.13 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10267
- Expression level (log2 read counts): 6.15
Expression Distribution
ACSS1 Expression in NALM6 Cells: 6.15
