ADCY10

Entrez Summary: The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014].
UniProt Summary: Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988). {ECO:0000250|UniProtKB:Q8C0T9, ECO:0000269|PubMed:15659711, ECO:0000269|PubMed:17591988, ECO:0000269|PubMed:24567411, ECO:0000269|PubMed:24616449, ECO:0000269|PubMed:25040695}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
MS023 7μM R03 exp135	-2.06
Menadione 5μM R06 exp292	1.74

bicarbonate binding
adenylate cyclase activity
cAMP biosynthetic process
basal part of cell
cAMP metabolic process
cyclic nucleotide biosynthetic process
cyclic purine nucleotide metabolic process
epithelial cilium movement involved in extracellular fluid movement
extracellular transport
cyclic nucleotide metabolic process
cilium movement
manganese ion binding
ATPase binding
motile cilium
growth cone
purine ribonucleotide biosynthetic process
microtubule cytoskeleton
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
microtubule-based transport
magnesium ion binding
cellular response to inorganic substance
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
microtubule-based movement
purine ribonucleotide metabolic process
apical plasma membrane
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
neuronal cell body
dendrite
nucleotide metabolic process
nucleoside phosphate metabolic process
response to inorganic substance
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process