ADCY4
Gene Information
- Official Symbol: ADCY4
- Official Name: adenylate cyclase 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 196883
- UniProt: Q8NFM4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. {ECO:0000250|UniProtKB:P26770}.
Pfam Domains GO Terms
Pfam Domains
| Guanylate cyc |
| DUF1053 |
GO Terms
| adenylate cyclase activity |
| cAMP biosynthetic process |
| activation of protein kinase A activity |
| cAMP metabolic process |
| cyclic nucleotide biosynthetic process |
| cyclic purine nucleotide metabolic process |
| cellular response to glucagon stimulus |
| renal water homeostasis |
| response to glucagon |
| activation of adenylate cyclase activity |
| cyclic nucleotide metabolic process |
| protein kinase C binding |
| multicellular organismal water homeostasis |
| water homeostasis |
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| renal system process |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| cAMP-mediated signaling |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| cyclic-nucleotide-mediated signaling |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| nucleotide biosynthetic process |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| nucleoside phosphate biosynthetic process |
| cellular response to peptide hormone stimulus |
| purine ribonucleotide metabolic process |
| multicellular organismal homeostasis |
| ribonucleotide metabolic process |
| cellular response to peptide |
| activation of protein kinase activity |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| second-messenger-mediated signaling |
| purine-containing compound metabolic process |
| response to peptide hormone |
| dendrite |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| response to peptide |
| regulation of body fluid levels |
| positive regulation of protein kinase activity |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| positive regulation of kinase activity |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| carbohydrate derivative biosynthetic process |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| regulation of protein kinase activity |
| regulation of kinase activity |
| organophosphate metabolic process |
| response to hormone |
| regulation of transferase activity |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| carbohydrate derivative metabolic process |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| chemical homeostasis |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| organic cyclic compound biosynthetic process |
| G protein-coupled receptor signaling pathway |
| integral component of plasma membrane |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| ATP binding |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| small molecule metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| system process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| 5-Azacytidine 2μM R07 exp330 | -2.25 |
| 6-Thio-2-deoxyguanosine 2μM R06 exp259 | -1.82 |
| THZ531 0.11μM R07 exp409 | -1.77 |
| Cytochalasin-B 5μM R07 exp349 | -1.75 |
| Tenofovir 10μM R07 exp405 | -1.75 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12669
- Expression level (log2 read counts): 0.71
Expression Distribution
ADCY4 Expression in NALM6 Cells: 0.71
