ADCY8
Gene Information
- Official Symbol: ADCY8
- Official Name: adenylate cyclase 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 114
- UniProt: P40145
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Guanylate cyc |
| DUF1053 |
GO Terms
| calcium- and calmodulin-responsive adenylate cyclase activity |
| sugar mediated signaling pathway |
| hexose mediated signaling |
| glucose mediated signaling pathway |
| cellular response to isoquinoline alkaloid |
| cellular response to morphine |
| carbohydrate mediated signaling |
| positive regulation of long-term synaptic depression |
| opioid receptor signaling pathway |
| adenylate cyclase activity |
| cAMP biosynthetic process |
| cellular response to forskolin |
| response to forskolin |
| positive regulation of synaptic plasticity |
| response to platelet aggregation inhibitor |
| regulation of long-term synaptic depression |
| activation of protein kinase A activity |
| positive regulation of CREB transcription factor activity |
| positive regulation of long-term synaptic potentiation |
| cAMP metabolic process |
| cyclic purine nucleotide metabolic process |
| cyclic nucleotide biosynthetic process |
| cellular response to glucagon stimulus |
| neuronal cell body membrane |
| plasma membrane raft |
| excitatory synapse |
| long-term memory |
| protein phosphatase 2A binding |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| response to morphine |
| response to isoquinoline alkaloid |
| hippocampal mossy fiber to CA3 synapse |
| renal water homeostasis |
| presynaptic active zone |
| cellular response to alkaloid |
| response to glucagon |
| activation of adenylate cyclase activity |
| neuroinflammatory response |
| cyclic nucleotide metabolic process |
| regulation of long-term synaptic potentiation |
| clathrin-coated vesicle membrane |
| clathrin-coated pit |
| regulation of insulin secretion involved in cellular response to glucose stimulus |
| integral component of presynaptic membrane |
| multicellular organismal water homeostasis |
| cellular response to glucose stimulus |
| cellular response to hexose stimulus |
| cellular response to monosaccharide stimulus |
| positive regulation of insulin secretion |
| water homeostasis |
| caveola |
| response to anesthetic |
| cellular response to carbohydrate stimulus |
| Schaffer collateral - CA1 synapse |
| cellular response to calcium ion |
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| cellular response to alcohol |
| cellular glucose homeostasis |
| cellular response to ketone |
| positive regulation of peptide hormone secretion |
| renal system process |
| response to alkaloid |
| memory |
| cellular response to antibiotic |
| positive regulation of hormone secretion |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| cellular response to ammonium ion |
| response to glucose |
| response to hexose |
| cAMP-mediated signaling |
| purine ribonucleotide biosynthetic process |
| response to monosaccharide |
| positive regulation of synaptic transmission |
| response to calcium ion |
| purine nucleotide biosynthetic process |
| protein dimerization activity |
| ribonucleotide biosynthetic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| response to carbohydrate |
| cyclic-nucleotide-mediated signaling |
| regulation of insulin secretion |
| response to ammonium ion |
| glucose homeostasis |
| carbohydrate homeostasis |
| cellular response to xenobiotic stimulus |
| regulation of synaptic plasticity |
| cellular response to metal ion |
| response to ketone |
| locomotory behavior |
| basolateral plasma membrane |
| postsynaptic membrane |
| calmodulin binding |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| regulation of peptide hormone secretion |
| actin cytoskeleton |
| cellular response to inorganic substance |
| membrane raft |
| response to alcohol |
| nucleotide biosynthetic process |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| nucleoside phosphate biosynthetic process |
| postsynaptic density |
| learning or memory |
| positive regulation of DNA-binding transcription factor activity |
| cellular response to peptide hormone stimulus |
| regulation of hormone secretion |
| actin binding |
| positive regulation of protein secretion |
| positive regulation of cytosolic calcium ion concentration |
| positive regulation of peptide secretion |
| axon |
| cognition |
| response to xenobiotic stimulus |
| response to antibiotic |
| purine ribonucleotide metabolic process |
| apical plasma membrane |
| multicellular organismal homeostasis |
| ribonucleotide metabolic process |
| cellular response to peptide |
| regulation of cytosolic calcium ion concentration |
| activation of protein kinase activity |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| second-messenger-mediated signaling |
| protein homooligomerization |
| glutamatergic synapse |
| purine-containing compound metabolic process |
| response to metal ion |
| response to peptide hormone |
| positive regulation of secretion by cell |
| cellular response to drug |
| dendrite |
| positive regulation of protein transport |
| regulation of DNA-binding transcription factor activity |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| nucleotide metabolic process |
| calcium ion homeostasis |
| nucleoside phosphate metabolic process |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| response to peptide |
| protein heterodimerization activity |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| regulation of body fluid levels |
| inflammatory response |
| protein complex oligomerization |
| cellular response to lipid |
| regulation of hormone levels |
| positive regulation of protein kinase activity |
| response to inorganic substance |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| cellular response to organic cyclic compound |
| cell junction |
| cellular metal ion homeostasis |
| behavior |
| positive regulation of kinase activity |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| carbohydrate derivative biosynthetic process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| cation homeostasis |
| regulation of protein transport |
| inorganic ion homeostasis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| ion homeostasis |
| regulation of protein kinase activity |
| regulation of secretion |
| response to lipid |
| regulation of kinase activity |
| protein homodimerization activity |
| organophosphate metabolic process |
| cellular homeostasis |
| response to hormone |
| regulation of cellular localization |
| response to organic cyclic compound |
| regulation of transferase activity |
| positive regulation of transport |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| response to drug |
| carbohydrate derivative metabolic process |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| chemical homeostasis |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| organic cyclic compound biosynthetic process |
| G protein-coupled receptor signaling pathway |
| defense response |
| nervous system process |
| integral component of plasma membrane |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| ATP binding |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| small molecule metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| system process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.412 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11516
- Expression level (log2 read counts): -5.28
Expression Distribution
ADCY8 Expression in NALM6 Cells: -5.28
