ADD1

Gene Information

Official Symbol: ADD1
Official Name: adducin 1
Aliases and Previous Symbols: N/A
Entrez ID: 118
UniProt: P35611
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7587
Expression level (log2 read counts): 7.2

Expression Distribution

Screen	Score
Myriocin 25μM R06 exp293	-1.91
R-DABN 8μM R03 exp111	-1.77

positive regulation of endothelial cell development
positive regulation of establishment of endothelial barrier
F-actin capping protein complex
hemoglobin metabolic process
regulation of endothelial cell development
regulation of establishment of endothelial barrier
barbed-end actin filament capping
positive regulation of endothelial cell differentiation
cell volume homeostasis
spectrin binding
homeostasis of number of cells within a tissue
plasma membrane raft
positive regulation of adherens junction organization
actin filament capping
regulation of endothelial cell differentiation
negative regulation of actin filament depolymerization
regulation of actin filament depolymerization
negative regulation of actin filament polymerization
IRE1-mediated unfolded protein response
positive regulation of epithelial cell differentiation
negative regulation of protein depolymerization
actin filament bundle assembly
actin filament bundle organization
negative regulation of protein polymerization
regulation of adherens junction organization
negative regulation of protein complex disassembly
erythrocyte differentiation
multicellular organism growth
cellular response to calcium ion
regulation of protein depolymerization
erythrocyte homeostasis
positive regulation of protein binding
structural constituent of cytoskeleton
endoplasmic reticulum unfolded protein response
cell-cell adherens junction
myeloid cell homeostasis
regulation of protein complex disassembly
cellular response to unfolded protein
negative regulation of protein complex assembly
negative regulation of supramolecular fiber organization