ADORA1
Gene Information
- Official Symbol: ADORA1
- Official Name: adenosine A1 receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 134
- UniProt: P30542
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
| 7TM GPCR Srsx |
GO Terms
| positive regulation of nucleoside transport |
| regulation of nucleoside transport |
| neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration |
| negative regulation of mucus secretion |
| negative regulation of neurotrophin production |
| negative regulation of circadian sleep/wake cycle, non-REM sleep |
| purine nucleoside binding |
| negative regulation of long-term synaptic depression |
| regulation of neurotrophin production |
| negative regulation of renal sodium excretion |
| heterotrimeric G-protein binding |
| negative regulation of glutamate secretion |
| negative regulation of circadian sleep/wake cycle, sleep |
| G protein-coupled adenosine receptor activity |
| negative regulation of synaptic transmission, GABAergic |
| relaxation of vascular smooth muscle |
| relaxation of smooth muscle |
| regulation of circadian sleep/wake cycle, non-REM sleep |
| adenosine receptor signaling pathway |
| positive regulation of nucleobase-containing compound transport |
| negative regulation of synaptic transmission, glutamatergic |
| regulation of mucus secretion |
| negative regulation of amino acid transport |
| positive regulation of epidermal growth factor-activated receptor activity |
| regulation of glomerular filtration |
| negative regulation of long-term synaptic potentiation |
| negative regulation of acute inflammatory response |
| regulation of respiratory gaseous exchange by nervous system process |
| negative regulation of smooth muscle contraction |
| axolemma |
| fatty acid homeostasis |
| regulation of long-term synaptic depression |
| positive regulation of systemic arterial blood pressure |
| negative regulation of circadian rhythm |
| detection of temperature stimulus involved in sensory perception |
| detection of temperature stimulus involved in sensory perception of pain |
| regulation of glutamate secretion |
| renal system process involved in regulation of blood volume |
| regulation of respiratory system process |
| regulation of nucleobase-containing compound transport |
| negative regulation of behavior |
| regulation of presynaptic cytosolic calcium ion concentration |
| regulation of circadian sleep/wake cycle, sleep |
| negative regulation of systemic arterial blood pressure |
| detection of temperature stimulus |
| G protein-coupled purinergic receptor signaling pathway |
| G-protein beta/gamma-subunit complex binding |
| negative regulation of organic acid transport |
| regulation of circadian sleep/wake cycle |
| relaxation of muscle |
| regulation of renal sodium excretion |
| sensory perception of temperature stimulus |
| negative regulation of muscle contraction |
| regulation of respiratory gaseous exchange |
| negative regulation of lipid catabolic process |
| regulation of excretion |
| positive regulation of lipid catabolic process |
| negative regulation of heart contraction |
| calyx of Held |
| renal system process involved in regulation of systemic arterial blood pressure |
| negative regulation of amine transport |
| regulation of epidermal growth factor-activated receptor activity |
| purinergic receptor signaling pathway |
| negative regulation of anion transport |
| temperature homeostasis |
| vasodilation |
| positive regulation of epidermal growth factor receptor signaling pathway |
| regulation of amino acid transport |
| regulation of synaptic transmission, GABAergic |
| positive regulation of ERBB signaling pathway |
| negative regulation of blood circulation |
| neuron cellular homeostasis |
| positive regulation of signaling receptor activity |
| regulation of renal system process |
| acylglycerol homeostasis |
| presynaptic active zone |
| triglyceride homeostasis |
| positive regulation of blood pressure |
| regulation of cardiac muscle cell contraction |
| regulation of sensory perception of pain |
| negative regulation of blood vessel diameter |
| regulation of sensory perception |
| regulation of actin filament-based movement |
| regulation of long-term synaptic potentiation |
| positive regulation of protein dephosphorylation |
| regulation of acute inflammatory response |
| positive regulation of potassium ion transport |
| negative regulation of blood pressure |
| integral component of postsynaptic membrane |
| negative regulation of leukocyte migration |
| terminal bouton |
| activation of MAPKK activity |
| regulation of lipid catabolic process |
| positive regulation of protein tyrosine kinase activity |
| positive regulation of blood vessel diameter |
| anion homeostasis |
| integral component of presynaptic membrane |
| regulation of organic acid transport |
| heat shock protein binding |
| positive regulation of dephosphorylation |
| regulation of smooth muscle contraction |
| negative regulation of synaptic transmission |
| excitatory postsynaptic potential |
| negative regulation of hormone secretion |
| G protein-coupled receptor binding |
| chemical synaptic transmission, postsynaptic |
| regulation of synaptic transmission, glutamatergic |
| regulation of behavior |
| sensory perception of pain |
| regulation of cardiac muscle contraction |
| negative regulation of lipid metabolic process |
| regulation of epidermal growth factor receptor signaling pathway |
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| regulation of protein tyrosine kinase activity |
| regulation of ERBB signaling pathway |
| regulation of striated muscle contraction |
| positive regulation of neuron death |
| regulation of amine transport |
| regulation of systemic arterial blood pressure |
| regulation of potassium ion transport |
| regulation of anion transport |
| regulation of postsynaptic membrane potential |
| renal system process |
| regulation of circadian rhythm |
| detection of external stimulus |
| detection of abiotic stimulus |
| lipid homeostasis |
| negative regulation of inflammatory response |
| regulation of nervous system process |
| regulation of tube diameter |
| regulation of blood vessel diameter |
| regulation of tube size |
| regulation of protein dephosphorylation |
| positive regulation of lipid metabolic process |
| negative regulation of ion transport |
| dendritic spine |
| positive regulation of synaptic transmission |
| protein targeting to membrane |
| regulation of muscle contraction |
| vascular process in circulatory system |
| regulation of signaling receptor activity |
| response to temperature stimulus |
| regulation of blood pressure |
| regulation of synaptic plasticity |
| positive regulation of peptidyl-tyrosine phosphorylation |
| regulation of leukocyte migration |
| basolateral plasma membrane |
| negative regulation of secretion by cell |
| negative regulation of defense response |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| regulation of dephosphorylation |
| negative regulation of secretion |
| regulation of muscle system process |
| regulation of heart contraction |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| postsynaptic density |
| regulation of peptidyl-tyrosine phosphorylation |
| negative regulation of cell migration |
| positive regulation of MAP kinase activity |
| establishment of protein localization to membrane |
| regulation of hormone secretion |
| negative regulation of cell motility |
| positive regulation of ion transport |
| apoptotic signaling pathway |
| regulation of blood circulation |
| positive regulation of peptide secretion |
| lipid catabolic process |
| cognition |
| muscle system process |
| negative regulation of cellular component movement |
| negative regulation of catabolic process |
| regulation of neuron death |
| negative regulation of locomotion |
| multicellular organismal homeostasis |
| regulation of cytosolic calcium ion concentration |
| activation of protein kinase activity |
| phagocytosis |
| regulation of inflammatory response |
| positive regulation of protein serine/threonine kinase activity |
| anatomical structure homeostasis |
| regulation of MAP kinase activity |
| response to hypoxia |
| protein targeting |
| response to decreased oxygen levels |
| negative regulation of response to external stimulus |
| neuronal cell body |
| response to oxygen levels |
| regulation of metal ion transport |
| regulation of actin filament-based process |
| blood circulation |
| regulation of lipid metabolic process |
| circulatory system process |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of membrane potential |
| positive regulation of catabolic process |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| negative regulation of immune system process |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| synaptic signaling |
| cellular divalent inorganic cation homeostasis |
| protein localization to membrane |
| negative regulation of transport |
| protein heterodimerization activity |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| regulation of body fluid levels |
| inflammatory response |
| regulation of anatomical structure size |
| regulation of protein serine/threonine kinase activity |
| regulation of hormone levels |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| detection of stimulus involved in sensory perception |
| cellular metal ion homeostasis |
| positive regulation of kinase activity |
| regulation of system process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| positive regulation of transferase activity |
| negative regulation of cell population proliferation |
| detection of stimulus |
| positive regulation of cell death |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| ion homeostasis |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of cell migration |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| apoptotic process |
| sensory perception |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| intracellular protein transport |
| regulation of catabolic process |
| negative regulation of cell death |
| endoplasmic reticulum |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| programmed cell death |
| positive regulation of phosphorylation |
| cell death |
| regulation of response to external stimulus |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| positive regulation of protein modification process |
| G protein-coupled receptor signaling pathway |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| nervous system process |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| regulation of apoptotic process |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| regulation of transport |
| vesicle-mediated transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Resveratrol 16μM R03 exp147 | -2.08 |
| Rotenone 2μM R00 exp33 | -1.97 |
| Brefeldin A 0.02μM R00 exp8 | -1.82 |
| Pifithrin-alpha 20μM R07 exp390 | -1.79 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.462 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10582
- Expression level (log2 read counts): -1.24
Expression Distribution
ADORA1 Expression in NALM6 Cells: -1.24
