ADRBK2

Entrez Summary: N/A
UniProt Summary: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
TRAIL 5ng/ml R00 exp35	-1.82
Nicotinamide 2000μM R01 exp50	1.77

beta-adrenergic receptor kinase activity
G protein-coupled receptor kinase activity
receptor internalization
receptor metabolic process
receptor-mediated endocytosis
protein kinase activity
endocytosis
import into cell
protein phosphorylation
phosphorylation
G protein-coupled receptor signaling pathway
ATP binding
vesicle-mediated transport