AGAP2

Gene Information

Official Symbol: AGAP2
Official Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Aliases and Previous Symbols: N/A
Entrez ID: 116986
UniProt: Q99490
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
UniProt Summary: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3224
Expression level (log2 read counts): 4.37

Expression Distribution

Screen	Score
A-769662 20μM R07 exp331	1.71
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.8
BN82002 4μM R07 exp340	1.81

ArfGap
Miro
Ank 2
PH
Ras

regulation of 1-phosphatidylinositol-3-kinase activity
positive regulation of 1-phosphatidylinositol-3-kinase activity
positive regulation of phosphatidylinositol biosynthetic process
regulation of phosphatidylinositol biosynthetic process
positive regulation of phospholipid biosynthetic process
regulation of phospholipid biosynthetic process
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of lipid kinase activity
positive regulation of phospholipid metabolic process
regulation of phosphatidylinositol 3-kinase activity
regulation of lipid kinase activity
positive regulation of lipid biosynthetic process
regulation of phospholipid metabolic process
negative regulation of protein catabolic process
positive regulation of lipid metabolic process
negative regulation of neuron apoptotic process
regulation of lipid biosynthetic process
negative regulation of neuron death
regulation of neuron apoptotic process
GTPase activator activity
negative regulation of catabolic process
regulation of neuron death
GTPase activity
regulation of protein catabolic process
GTP binding
regulation of lipid metabolic process
positive regulation of GTPase activity
regulation of GTPase activity
positive regulation of kinase activity
positive regulation of transferase activity
positive regulation of hydrolase activity
nucleolus
regulation of kinase activity
negative regulation of apoptotic process
negative regulation of programmed cell death
regulation of transferase activity
regulation of catabolic process
negative regulation of cell death
positive regulation of phosphorylation
negative regulation of protein metabolic process