AGR2

Gene Information

Official Symbol: AGR2
Official Name: anterior gradient 2, protein disulphide isomerase family member
Aliases and Previous Symbols: N/A
Entrez ID: 10551
UniProt: O95994
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113). {ECO:0000250, ECO:0000269|PubMed:18199544, ECO:0000269|PubMed:23274113}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10632
Expression level (log2 read counts): -5.6

Expression Distribution

Screen	Score
Nocodazole 0.1μM R03 exp94	2.06
HMS-I1 10μM R06 exp256	2.24
Nocodazole 0.2μM R00 exp24	2.39
SB743921 0.001μM R05 exp244	2.65

lung goblet cell differentiation
positive regulation of PERK-mediated unfolded protein response
lobar bronchus epithelium development
mucus secretion
lobar bronchus development
positive regulation of IRE1-mediated unfolded protein response
lung secretory cell differentiation
regulation of PERK-mediated unfolded protein response
bronchus development
dystroglycan binding
regulation of IRE1-mediated unfolded protein response
positive regulation of endoplasmic reticulum unfolded protein response
secretion by tissue
lung epithelial cell differentiation
lung cell differentiation
regulation of endoplasmic reticulum unfolded protein response
lung epithelium development
positive regulation of epidermal growth factor receptor signaling pathway
epidermal growth factor receptor binding
positive regulation of ERBB signaling pathway
positive regulation of response to endoplasmic reticulum stress
glandular epithelial cell differentiation
digestive tract morphogenesis
positive regulation of protein localization to plasma membrane
positive regulation of protein localization to cell periphery
carbohydrate derivative transport
body fluid secretion
regulation of response to endoplasmic reticulum stress
regulation of epidermal growth factor receptor signaling pathway
regulation of ERBB signaling pathway
regulation of protein localization to plasma membrane
columnar/cuboidal epithelial cell differentiation
regulation of protein localization to cell periphery
positive regulation of cell-substrate adhesion
positive regulation of protein localization to membrane
digestive tract development
digestive system development
lung development
positive regulation of developmental growth
respiratory tube development