AGTR1

Gene Information

Official Symbol: AGTR1
Official Name: angiotensin II receptor type 1
Aliases and Previous Symbols: N/A
Entrez ID: 185
UniProt: P30556
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012].
UniProt Summary: Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11401
Expression level (log2 read counts): -6.6

Expression Distribution

7TM GPCR Srsx
7tm 1

angiotensin type I receptor activity
phospholipase C-activating angiotensin-activated signaling pathway
bradykinin receptor binding
angiotensin type II receptor activity
renin-angiotensin regulation of aldosterone production
renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
regulation of blood vessel diameter by renin-angiotensin
regulation of aldosterone secretion
regulation of mineralocorticoid secretion
positive regulation of phospholipase A2 activity
positive regulation of NAD(P)H oxidase activity
regulation of blood volume by renin-angiotensin
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
positive regulation of cholesterol esterification
angiotensin-activated signaling pathway
regulation of cholesterol esterification
regulation of NAD(P)H oxidase activity
regulation of phospholipase A2 activity
low-density lipoprotein particle remodeling
regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
positive regulation of macrophage derived foam cell differentiation
regulation of corticosteroid hormone secretion
regulation of steroid hormone secretion
regulation of renal sodium excretion
cellular response to angiotensin
regulation of systemic arterial blood pressure by renin-angiotensin
renal system process involved in regulation of systemic arterial blood pressure
regulation of excretion
response to angiotensin
positive regulation of steroid metabolic process
plasma lipoprotein particle remodeling
protein-lipid complex remodeling
protein-containing complex remodeling
regulation of macrophage derived foam cell differentiation
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
regulation of renal system process
regulation of systemic arterial blood pressure by hormone
positive regulation of sprouting angiogenesis
plasma lipoprotein particle organization
regulation of endocrine process