AGTR2
Gene Information
- Official Symbol: AGTR2
- Official Name: angiotensin II receptor type 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 186
- UniProt: P50052
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. [provided by RefSeq, Jan 2010].
- UniProt Summary: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. {ECO:0000269|PubMed:15123706}.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure |
| mineralocorticoid secretion |
| aldosterone secretion |
| regulation of metanephros size |
| G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger |
| corticosteroid hormone secretion |
| brain renin-angiotensin system |
| angiotensin type II receptor activity |
| renin-angiotensin regulation of aldosterone production |
| negative regulation of icosanoid secretion |
| negative regulation of neurotrophin TRK receptor signaling pathway |
| regulation of blood vessel diameter by renin-angiotensin |
| renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure |
| lipid export from cell |
| positive regulation of metanephric glomerulus development |
| regulation of kidney size |
| steroid hormone secretion |
| regulation of aldosterone secretion |
| regulation of mineralocorticoid secretion |
| regulation of metanephric glomerulus development |
| regulation of blood volume by renin-angiotensin |
| negative regulation of norepinephrine secretion |
| negative regulation of fatty acid transport |
| physiological cardiac muscle hypertrophy |
| physiological muscle hypertrophy |
| cell growth involved in cardiac muscle cell development |
| dopamine biosynthetic process |
| angiotensin-activated signaling pathway |
| negative regulation of heart rate |
| positive regulation of glomerulus development |
| endocrine hormone secretion |
| nervous system process involved in regulation of systemic arterial blood pressure |
| regulation of neurotrophin TRK receptor signaling pathway |
| positive regulation of metanephros development |
| positive regulation of renal sodium excretion |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin |
| regulation of glomerulus development |
| negative regulation of catecholamine secretion |
| regulation of norepinephrine secretion |
| regulation of corticosteroid hormone secretion |
| cellular sodium ion homeostasis |
| negative regulation of systemic arterial blood pressure |
| positive regulation of branching involved in ureteric bud morphogenesis |
| regulation of icosanoid secretion |
| catechol-containing compound biosynthetic process |
| regulation of steroid hormone secretion |
| catecholamine biosynthetic process |
| negative regulation of organic acid transport |
| nitric oxide mediated signal transduction |
| cellular response to angiotensin |
| regulation of renal sodium excretion |
| positive regulation of phosphoprotein phosphatase activity |
| positive regulation of mesonephros development |
| positive regulation of nitric-oxide synthase activity |
| regulation of branching involved in ureteric bud morphogenesis |
| regulation of systemic arterial blood pressure by renin-angiotensin |
| regulation of metanephros development |
| negative regulation of heart contraction |
| renal system process involved in regulation of systemic arterial blood pressure |
| regulation of excretion |
| negative regulation of amine transport |
| regulation of mesonephros development |
| exploration behavior |
| negative regulation of lipid transport |
| response to angiotensin |
| regulation of fatty acid transport |
| metanephros morphogenesis |
| cardiac muscle tissue growth |
| positive regulation of monooxygenase activity |
| negative regulation of anion transport |
| receptor antagonist activity |
| heart growth |
| cardiac muscle hypertrophy |
| negative regulation of fibroblast proliferation |
| dopamine metabolic process |
| vasodilation |
| cellular response to dexamethasone stimulus |
| striated muscle hypertrophy |
| negative regulation of blood vessel endothelial cell migration |
| muscle hypertrophy |
| blood vessel remodeling |
| sodium ion homeostasis |
| negative regulation of blood circulation |
| positive regulation of phosphatase activity |
| positive regulation of morphogenesis of an epithelium |
| phenol-containing compound biosynthetic process |
| regulation of renal system process |
| regulation of systemic arterial blood pressure by hormone |
| positive regulation of nitric oxide biosynthetic process |
| positive regulation of nitric oxide metabolic process |
| positive regulation of kidney development |
| response to dexamethasone |
| negative regulation of lipid localization |
| catecholamine metabolic process |
| regulation of endocrine process |
| positive regulation of protein dephosphorylation |
| regulation of nitric-oxide synthase activity |
| catechol-containing compound metabolic process |
| negative regulation of blood pressure |
| regulation of systemic arterial blood pressure mediated by a chemical signal |
| cerebellar cortex development |
| endocrine process |
| negative regulation of endothelial cell migration |
| positive regulation of extrinsic apoptotic signaling pathway |
| positive regulation of reactive oxygen species biosynthetic process |
| positive regulation of oxidoreductase activity |
| regulation of monooxygenase activity |
| regulation of protein import into nucleus |
| regulation of kidney development |
| regulation of nitric oxide biosynthetic process |
| cellular response to glucocorticoid stimulus |
| regulation of morphogenesis of a branching structure |
| positive regulation of blood vessel diameter |
| regulation of organic acid transport |
| positive regulation of dephosphorylation |
| negative regulation of signaling receptor activity |
| regulation of protein import |
| cellular response to corticosteroid stimulus |
| cardiac muscle cell development |
| regulation of catecholamine secretion |
| cardiac cell development |
| negative regulation of epithelial cell migration |
| hormone secretion |
| regulation of fibroblast proliferation |
| hormone transport |
| positive regulation of animal organ morphogenesis |
| phenol-containing compound metabolic process |
| metanephros development |
| kidney morphogenesis |
| regulation of reactive oxygen species biosynthetic process |
| developmental cell growth |
| cardiac muscle cell differentiation |
| cell growth |
| regulation of blood vessel endothelial cell migration |
| cellular response to ketone |
| regulation of systemic arterial blood pressure |
| regulation of amine transport |
| response to antineoplastic agent |
| regulation of anion transport |
| regulation of oxidoreductase activity |
| positive regulation of reactive oxygen species metabolic process |
| organ growth |
| regulation of heart rate |
| tissue remodeling |
| cerebellum development |
| regulation of nucleocytoplasmic transport |
| regulation of lipid transport |
| cellular monovalent inorganic cation homeostasis |
| renal system process |
| metencephalon development |
| cardiocyte differentiation |
| regulation of protein localization to nucleus |
| regulation of phosphoprotein phosphatase activity |
| striated muscle cell development |
| organic hydroxy compound transport |
| regulation of lipid localization |
| positive regulation of cytokine secretion |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of tube size |
| monovalent inorganic cation homeostasis |
| regulation of protein dephosphorylation |
| response to glucocorticoid |
| negative regulation of ion transport |
| negative regulation of cellular response to growth factor stimulus |
| muscle cell development |
| hindbrain development |
| regulation of extrinsic apoptotic signaling pathway |
| regulation of endothelial cell migration |
| response to corticosteroid |
| cardiac muscle tissue development |
| signal release |
| vascular process in circulatory system |
| regulation of signaling receptor activity |
| positive regulation of apoptotic signaling pathway |
| regulation of phosphatase activity |
| regulation of reactive oxygen species metabolic process |
| regulation of morphogenesis of an epithelium |
| regulation of blood pressure |
| negative regulation of cell growth |
| organic hydroxy compound biosynthetic process |
| cellular response to xenobiotic stimulus |
| cellular response to steroid hormone stimulus |
| ammonium ion metabolic process |
| response to ketone |
| striated muscle cell differentiation |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| regulation of dephosphorylation |
| regulation of epithelial cell migration |
| regulation of intracellular protein transport |
| negative regulation of secretion |
| regulation of heart contraction |
| negative regulation of growth |
| muscle cell differentiation |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| regulation of animal organ morphogenesis |
| negative regulation of cell migration |
| cellular response to peptide hormone stimulus |
| kidney development |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| regulation of cellular response to growth factor stimulus |
| negative regulation of cell motility |
| renal system development |
| striated muscle tissue development |
| regulation of blood circulation |
| positive regulation of peptide secretion |
| muscle tissue development |
| lipid transport |
| muscle system process |
| response to xenobiotic stimulus |
| negative regulation of cellular component movement |
| urogenital system development |
| lipid localization |
| negative regulation of locomotion |
| cellular response to peptide |
| response to steroid hormone |
| transcription factor binding |
| second-messenger-mediated signaling |
| regulation of intracellular transport |
| regulation of neurotransmitter levels |
| developmental growth |
| blood circulation |
| response to peptide hormone |
| growth |
| circulatory system process |
| regulation of apoptotic signaling pathway |
| positive regulation of secretion by cell |
| cellular response to drug |
| regulation of cell growth |
| positive regulation of protein transport |
| positive regulation of secretion |
| positive regulation of cytokine production |
| organic hydroxy compound metabolic process |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| response to peptide |
| muscle structure development |
| negative regulation of transport |
| regulation of peptide secretion |
| inflammatory response |
| drug metabolic process |
| regulation of anatomical structure size |
| cellular response to lipid |
| heart development |
| regulation of hormone levels |
| regulation of cellular protein localization |
| cellular response to organic cyclic compound |
| cellular metal ion homeostasis |
| behavior |
| regulation of system process |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| positive regulation of programmed cell death |
| cellular response to nitrogen compound |
| regulation of growth |
| negative regulation of cell population proliferation |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| positive regulation of cell death |
| regulation of ion transport |
| regulation of protein transport |
| cation homeostasis |
| inorganic ion homeostasis |
| G protein-coupled receptor activity |
| regulation of peptide transport |
| brain development |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| positive regulation of hydrolase activity |
| head development |
| ion homeostasis |
| regulation of secretion |
| regulation of cell migration |
| response to lipid |
| circulatory system development |
| cellular homeostasis |
| response to hormone |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| response to organic cyclic compound |
| animal organ morphogenesis |
| central nervous system development |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| response to organonitrogen compound |
| secretion by cell |
| response to drug |
| regulation of protein localization |
| export from cell |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| chemical homeostasis |
| cell-cell signaling |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| aromatic compound biosynthetic process |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| organic cyclic compound biosynthetic process |
| G protein-coupled receptor signaling pathway |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| integral component of plasma membrane |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Chlorpromazine 10μM R07 exp344 | -1.7 |
| AICAR 240μM R05 exp211 | 2.03 |
| Bisphenol A 100μM R06 exp269 | 2.08 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/26 |
| bone | 0/26 |
| breast | 0/30 |
| central nervous system | 0/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 0/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 0/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18055
- Expression level (log2 read counts): -7.68
Expression Distribution
AGTR2 Expression in NALM6 Cells: -7.68
