AIDA

Gene Information

Official Symbol: AIDA
Official Name: axin interactor, dorsalization associated
Aliases and Previous Symbols: N/A
Entrez ID: 64853
UniProt: Q96BJ3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3897
Expression level (log2 read counts): 5.59

Expression Distribution

determination of ventral identity
determination of dorsal/ventral asymmetry
negative regulation of JUN kinase activity
regulation of protein homodimerization activity
negative regulation of JNK cascade
negative regulation of stress-activated protein kinase signaling cascade
negative regulation of stress-activated MAPK cascade
negative regulation of MAP kinase activity
dorsal/ventral pattern formation
phosphatidylinositol binding
regulation of JUN kinase activity
determination of bilateral symmetry
specification of symmetry
negative regulation of protein serine/threonine kinase activity
negative regulation of MAPK cascade
regulation of JNK cascade
regulation of protein binding
negative regulation of protein kinase activity
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
protein domain specific binding
negative regulation of kinase activity
negative regulation of transferase activity
regionalization
regulation of MAP kinase activity
regulation of binding
negative regulation of protein phosphorylation
pattern specification process
negative regulation of phosphorylation
cellular component
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of cellular response to stress
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity