AIMP1

Gene Information

Official Symbol: AIMP1
Official Name: aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 9255
UniProt: Q12904
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008].
UniProt Summary: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1- mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. {ECO:0000269|PubMed:10358004, ECO:0000269|PubMed:11157763, ECO:0000269|PubMed:11306575, ECO:0000269|PubMed:11818442, ECO:0000269|PubMed:12237313, ECO:0000269|PubMed:19362550}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18504
Expression level (log2 read counts): 5.79

Expression Distribution

positive regulation of glucagon secretion
regulation of glucagon secretion
aminoacyl-tRNA synthetase multienzyme complex
GTPase binding
negative regulation of endothelial cell proliferation
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
tRNA binding
positive regulation of peptide hormone secretion
negative regulation of epithelial cell proliferation
positive regulation of hormone secretion
regulation of endothelial cell proliferation
cytokine activity
tRNA metabolic process
defense response to virus
regulation of peptide hormone secretion
regulation of hormone secretion
response to virus
positive regulation of peptide secretion
cellular amino acid metabolic process
angiogenesis
regulation of epithelial cell proliferation
leukocyte migration
translation
positive regulation of secretion by cell
peptide biosynthetic process
blood vessel morphogenesis
positive regulation of secretion
ncRNA metabolic process
blood vessel development
regulation of peptide secretion
inflammatory response
vasculature development
cardiovascular system development
amide biosynthetic process
peptide metabolic process
regulation of hormone levels
chemotaxis
taxis