AK4

Gene Information

Official Symbol: AK4
Official Name: adenylate kinase 4
Aliases and Previous Symbols: N/A
Entrez ID: 205
UniProt: P27144
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000255|HAMAP-Rule:MF_03170, ECO:0000269|PubMed:19073142, ECO:0000269|PubMed:19766732, ECO:0000269|PubMed:23416111}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3504
Expression level (log2 read counts): 7.64

Expression Distribution

ADK
ADK lid

nucleoside triphosphate adenylate kinase activity
nucleoside monophosphate kinase activity
ADP biosynthetic process
purine ribonucleoside diphosphate biosynthetic process
ribonucleoside diphosphate biosynthetic process
purine nucleoside diphosphate biosynthetic process
nucleoside diphosphate biosynthetic process
adenylate kinase activity
nucleoside monophosphate phosphorylation
AMP metabolic process
regulation of ATP biosynthetic process
nucleoside diphosphate kinase activity
GTP metabolic process
nucleobase-containing small molecule interconversion
regulation of oxidative phosphorylation
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
regulation of purine nucleotide biosynthetic process
regulation of nucleotide biosynthetic process
guanosine-containing compound metabolic process
ADP metabolic process
ribonucleoside monophosphate metabolic process
nucleoside diphosphate phosphorylation
purine ribonucleoside triphosphate metabolic process
purine ribonucleoside metabolic process
purine nucleoside diphosphate metabolic process
nucleotide phosphorylation
purine ribonucleoside diphosphate metabolic process
nucleoside triphosphate biosynthetic process
ribonucleoside diphosphate metabolic process
purine nucleoside metabolic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
nucleoside monophosphate metabolic process
ribonucleoside metabolic process
nucleoside diphosphate metabolic process
nucleoside triphosphate metabolic process
nucleoside metabolic process
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process